• Accuracy of physical examination for chronic lumbar radiculopathy 

      Iversen, Trond; Solberg, Tore; Romner, Bertil; Wilsgaard, Tom; Nygaard, Øystein Petter; Waterloo, Knut; Brox, Jens Ivar; Ingebrigtsen, Tor (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      Background: Clinical examination of patients with chronic lumbar radiculopathy aims to clarify whether there is nerve root impingement. The aims of this study were to investigate the association between findings at clinical examination and nerve root impingement, to evaluate the accuracy of clinical index tests in a specialised care setting, and to see whether imaging clarifies the cause of chronic ...
    • Achievements of primary prevention targets in individuals with high risk of cardiovascular disease: an 8-year follow-up of the Tromsø study 

      Hagen, Amalie Nilsen; Ariansen, Inger Kristine Holtermann; Hanssen, Tove Aminda; Lappegård, Knut Tore; Eggen, Anne Elise; Løchen, Maja-Lisa; Njølstad, Inger; Wilsgaard, Tom; Hopstock, Laila Arnesdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-22)
      Aims To study change over 8 years in cardiovascular risk, achievement of national guideline-based treatment targets of lipids, blood pressure (BP) and smoking in primary prevention of cardiovascular disease (CVD), medication use, and characteristics associated with target achievement among individuals with high CVD risk in a general population.<p> <p>Methods and results We followed 2524 women ...
    • Age-specific atrial fibrillation incidence, attributable risk factors and risk of stroke and mortality: results from the MORGAM Consortium 

      Morseth, Bente; Geelhoed, Bastiaan; Linneberg, Allan; Johansson, Lars; Kuulasmaa, Kari; Salomaa, Veikko; Iacoviello, Licia; Constanzo, Simona; Söderberg, Stefan; Niiranen, Teemu; Vishram, Julie K.K.; Njølstad, Inger; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Løchen, Maja-Lisa; Zeller, Tanja; Blankenberg, Stefan; Ojeda, Francisco; Schnabel, Renate B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-02)
      <p><i>Background:</i> The main aim was to examine age-specific risk factor associations with incident atrial fibrillation (AF) and their attributable fraction in a large European cohort. Additionally, we aimed to examine risk of stroke and mortality in relation to new-onset AF across age. <p><i>Methods:</i> We used individual-level data (n=66 951, 49.1% men, age range 40–98 years at baseline) from ...
    • Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women 

      Frydenberg, Hanne; Flote, Vidar Gordon; Larsson, Ine Marie; Barrett, Emily S.; Furberg, Anne-Sofie; Ursin, Giske; Wilsgaard, Tom; Ellison, Peter; McTiernan, Anne; Hjartåker, Anette; Jasienska, Grazyna; Thune, Inger (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-07)
      Introduction: Alcohol consumption may promote aromatization of androgens to estrogens, which may partly explain the observations linking alcohol consumption to higher breast cancer risk. Whether alcohol consumption is associated with endogenous estrogen levels, and mammographic density phenotypes in premenopausal women remains unclear.<p> <p>Methods: Alcohol consumption was collected by self-report ...
    • Alcohol consumption, types of alcoholic beverages and risk of Venous Thromboembolism : the Tromsø Study 

      Hansen-Krone, Ida Johanne; Brækkan, Sigrid K.; Enga, Kristin F.; Wilsgaard, Tom; Hansen, John-Bjarne (Master thesis; Mastergradsoppgave, 2011-11-01)
      Moderate alcohol consumption has been shown to protect against cardiovascular diseases. The association between alcohol consumption, especially types of alcoholic beverages, and venous thromboembolism (VTE) is less well described. The aim of this study was to investigate the impact of alcohol consumption and different alcoholic beverages on risk of VTE. Information on alcohol consumption were ...
    • Anal incontinence, urinary incontinence and sexual problems in primiparous women - a comparison between women with episiotomy only and women with episiotomy and obstetric anal sphincter injury 

      Stedenfeldt, Mona; Pirhonen, Jouko; Blix, Ellen; Wilsgaard, Tom; Vonen, Barthold; Øian, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Analyses of Increased Mortality in New and Known Diabetes in Patients with Coronary Disease Enrolled in the NORSTENT Randomized Study 

      Mølstad, Per; Nordrehaug, Jan Erik; Steigen, Terje; Wilsgaard, Tom; Wiseth, Rune; Bønaa, Kaare Harald (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05)
      Background: NORSTENT trial randomized 9,013 patients to percutaneous coronary intervention with drug-eluting stents (DES) or bare-metal stents (BMS) with a 5-year follow-up. Among the patients, 5,512 had measured either fasting glucose level or percent glycated hemoglobin (HbA1c) at the index procedure. That cohort constitutes the present study population analyzing mortality and evaluating treatment ...
    • Assessment of mental health trajectories before and after myocardial infarction, atrial fibrillation or stroke: analysis of a cohort study in Tromsø, Norway (Tromsø Study, 1994-2016) 

      Lorem, Geir F; Opdal, Ida Marie; Wilsgaard, Tom; Schirmer, Henrik; Løchen, Maja-Lisa; Olsen, Ingrid Petrikke; Steigen, Terje; Rognmo, Kamilla (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-01)
      Objectives - The increased survival rate of cardiovascular disease (CVD) implies a higher proportion of individuals who live with CVD. Using data from the Tromsø Study, we aimed to investigate mental health symptom trajectories before and after myocardial infarction, atrial fibrillation or stroke in a general population and to explore factors that contribute to the association.<p> <p>Design - ...
    • Association between espresso coffee and serum total cholesterol: the Tromsø Study 2015-2016 

      Svatun, Åsne Lirhus; Løchen, Maja-Lisa; Thelle, Dag Steinar; Wilsgaard, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-10)
      Background - Coffee raises serum cholesterol because of its diterpenes, cafestol and kahweol, and the effect varies by brewing method. Population-based research on espresso coffee’s impact on serum cholesterol is scarce. Our aim was to examine how various brewing methods, in particular espresso, were associated with serum total cholesterol (S-TC).<p> <p>Methods - We used cross-sectional population ...
    • Association of glycated hemoglobin A1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium 

      Sinning, Christoph; Makarova, Nataliya; Völzke, Henry; Schnabel, Renate B.; Ojeda, Francisco; Dörr, Marcus; Felix, Stephan B.; Koenig, Wolfgang; Peters, Annette; Rathmann, Wolfgang; Schöttker, Ben; Brenner, Hermann; Veronesi, Giovanni; Cesana, Giancarlo; Brambilla, Paolo; Palosaari, Tarja; Kuulasmaa, Kari; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Blankenberg, Stefan; Söderberg, Stefan; Ferrario, Marco M.; Thorand, Barbara (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-15)
      Background: Biomarkers may contribute to improved cardiovascular risk estimation. Glycated hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) is used to monitor the quality of diabetes treatment. Its strength of association with cardiovascular outcomes in the general population remains uncertain. This study aims to assess the association of HbA<sub>1c</sub> with cardiovascular outcomes in the general ...
    • Association of occasional smoking with total mortality in the population-based Tromsø study, 2001-2015 

      Løchen, Maja-Lisa; Gram, Inger Torhild; Mannsverk, Jan T.; Mathiesen, Ellisiv B.; Njølstad, Inger; Schirmer, Henrik; Wilsgaard, Tom; Jacobsen, Bjarne K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-12-28)
      Objectives: <br> There is a shift in the smoking population from daily smokers to light or occasional smokers. The knowledge about possible adverse health effects of this new smoking pattern is limited. We investigated smoking habits with focus on occasional smoking in relation to total mortality in a follow-up study of a Norwegian general population. <br> Setting: <br> A population study ...
    • Associations between Common and Rare Exonic Genetic Variants and Serum Levels of 20 Cardiovascular-Related Proteins: The Tromsø Study 

      Solomon, Terry; Smith, Erin N.; Matsui, Hiroko; Brækkan, Sigrid Kufaas; Wilsgaard, Tom; Njølstad, Inger; Mathiesen, Ellisiv B.; Hansen, John-Bjarne; Frazer, Kelly A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-06-21)
      Background—Genetic variation can be used to study causal relationships between biomarkers and diseases. Here, we identify new common and rare genetic variants associated with cardiovascular-related protein levels (protein quantitative trait loci [pQTLs]). We functionally annotate these pQTLs, predict and experimentally confirm a novel molecular interaction, and determine which pQTLs are associated ...
    • Associations Between Intake of Fermented Dairy Products and Blood Lipid Concentrations Are Affected by Fat Content and Dairy Matrix - The Tromsø Study: Tromsø7 

      Machlik, Monika Lund; Hopstock, Laila Arnesdatter; Wilsgaard, Tom; Hansson, Patrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-22)
      Introduction: Dairy fat is rich in saturated fatty acids known to increase serum low-density lipoprotein cholesterol (LDL-C) concentration, an important risk factor for cardiovascular disease (CVD). However, intake of fermented dairy products has been associated with reduced CVD risk in observational studies. How intakes of different fermented dairy products are associated with blood lipid concentrations ...
    • Associations between postprandial triglyceride concentrations and sex, age, and body mass index: cross-sectional analyses from the Tromsø study 2015–2016 

      Mikkelsen, Mari; Wilsgaard, Tom; Grimsgaard, Sameline; Hopstock, Laila Arnesdatter; Hansson, Patrik (Journal article; Tidsskriftartikkel, 2023-06-15)
      Introduction: Elevated serum triglyceride concentrations increase the risk of developing atherosclerosis, the leading cause of cardiovascular disease. Postprandial triglyceride concentrations have shown to be a stronger predictor of cardiovascular disease compared to fasting triglycerides. It is therefore clinically relevant to study patterns of postprandial triglyceride concentrations in a general ...
    • Atherosclerotic risk factors and risk of myocardial infarction and venous thromboembolism; Time-fixed versus time-varying analyses. The Tromsø Study 

      Småbrekke, Birgit; Balteskard Rinde, Ludvig; Hindberg, Kristian; Mathiesen Hald, Erin; Vik, Anders; Wilsgaard, Tom; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Hansen, John-Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-16)
      <i>Background:</i> Single measurements of modifiable risk factors may underestimate associations with outcomes in cohorts. We aimed to compare risk estimates of myocardial infarction (MI) and venous thromboembolism (VTE) by atherosclerotic risk factors during long follow-up using time-fixed analyses without and with correction for regression dilution and time-varying analyses.<p> <p><i>Methods:</i> ...
    • Atrial Fibrillation and Cause-Specific Risks of Pulmonary Embolism and Ischemic Stroke 

      Hald, Erin Mathiesen; Rinde, Ludvig Balteskard; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-29)
      <p><i>Background</i>: Atrial fibrillation (AF) is a well‐established risk factor for ischemic stroke (IS). Emerging evidence also indicates an association between AF and pulmonary embolism (PE). Because IS may potentially mediate the observed risk of PE in AF, we aimed to assess the impact of AF on the cause‐specific risks of PE and IS in a large cohort recruited from the general population.</p> ...
    • Atrial fibrillation and future risk of venous thromboembolism:the Tromsø study 

      Enga, Kristin Fjeldstad; Rye Holmboe, Ina; Mathisen Hald, Erin; Løchen, Maja-Lisa; Mathiesen, Ellisiv B.; Njølstad, Inger; Wilsgaard, Tom; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Atrial fibrillation is associated with cognitive decline in stroke-free subjects: the Tromsø Study 

      Tiwari, Sweta; Løchen, Maja-Lisa; Jacobsen, Bjarne K.; Hopstock, Laila Arnesdatter; Nyrnes, Audhild; Njølstad, Inger; Mathiesen, Ellisiv B.; Arntzen, Kjell Arne; Ball, Jocasta; Stewart, Simon; Wilsgaard, Tom; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-28)
      Background and purpose:<br>Previous studies have shown associations between atrial fibrillation (AF) and cognitive decline. We investigated this association in a prospective population study, focusing on whether stroke risk factors modulated this association in stroke-free women and men.<br>Methods:<br>We included 4983 participants (57% women) from the fifth survey of the Tromsø Study (Tromsø 5, ...
    • Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromsø study 

      Hald, Erin Mathiesen; Løchen, Maja-Lisa; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid K.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-06)
      Background Atrial fibrillation (AF) is associated with increased risk of ischemic stroke and all‐cause mortality. Patients with AF are also at increased risk of venous thromboembolism (VTE), but information on how AF impacts VTE‐related mortality is scarce. Objectives - To investigate the impact of AF on all‐cause mortality in subjects with and without a thromboembolic event (VTE or ischemic ...
    • The bidirectional associations between leisure time physical activity change and body mass index gain. The Tromsø Study 1974–2016 

      Sagelv, Edvard Hamnvik; Ekelund, Ulf; Hopstock, Laila Arnesdatter; Fimland, Marius Steiro; Løvsletten, Ola; Wilsgaard, Tom; Morseth, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-18)
      Objectives: To examine whether leisure time physical activity changes predict subsequent body mass index (BMI) changes, and conversely, whether BMI changes predict subsequent leisure time physical activity changes. <p> <p>Methods: This prospective cohort study included adults attending ≥3 consecutive Tromsø Study surveys (time: T1, T2, T3) during 1974–2016 (n = 10779). If participants attended ...